NDAORALTABLET
Approved
Jul 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
TRIMETHOPRIM (trimethoprim) by Dr. Reddy's Laboratories is dihydrofolate reductase inhibitors [moa]. First approved in 1982.
Drug data last refreshed 19h ago · AI intelligence enriched 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Trimethoprim is a small-molecule oral dihydrofolate reductase inhibitor approved in 1982 for bacterial infections. It works by inhibiting bacterial folate synthesis, preventing nucleotide production essential for bacterial growth. This antibiotic is primarily used for urinary tract infections and other bacterial infections.
$9KPart D
LOE ApproachingMinimal commercial activity with very low Part D spending and claims volume suggests a mature, niche product with limited team expansion.
Mechanism of Action
Dihydrofolate Reductase Inhibitors
Pharmacologic Class:
Dihydrofolate Reductase Inhibitor Antibacterial
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Trimethoprim/Sulfamethoxazole Combined With Caspofungin as First-line Therapy in PCP
Started Aug 2019
122 enrolled
Pneumocystis Pneumonia
Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment
Started Nov 2018
269 enrolled
Methicillin-resistant Staphylococcus AureusSkin Infection
PK of Clindamycin and Trimethoprim-sulfamethoxazole in Infants and Children
Started Nov 2015
51 enrolled
Bacterial Infections
Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers
Started Feb 2015
70 enrolled
Anaemia
Daily Trimethoprim-sulfamethoxazole or Weekly Chloroquine Among Adults on ART in Malawi
Started Nov 2012
1,499 enrolled
HIV
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.