NDAORALTABLET
Approved
Jul 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
TRIMETHOPRIM (trimethoprim) by Dr. Reddy's Laboratories is dihydrofolate reductase inhibitors [moa]. First approved in 1982.
Drug data last refreshed 9h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Trimethoprim is a dihydrofolate reductase inhibitor antibacterial agent administered orally as a tablet for treating bacterial infections. It works by inhibiting bacterial dihydrofolate reductase, disrupting folate metabolism and DNA synthesis. This generic small molecule has been a foundational antibiotic since its 1982 approval.
$0.009BPart D
LOE ApproachingDeclining
Mature generic product with minimal Part D spending and low claim volume indicates a contracted team managing a legacy asset with limited growth opportunity.
Mechanism of Action
Dihydrofolate Reductase Inhibitors
Pharmacologic Class:
Dihydrofolate Reductase Inhibitor Antibacterial
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Trimethoprim/Sulfamethoxazole Combined With Caspofungin as First-line Therapy in PCP
Started Aug 2019
122 enrolled
Pneumocystis Pneumonia
Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment
Started Nov 2018
269 enrolled
Methicillin-resistant Staphylococcus AureusSkin Infection
PK of Clindamycin and Trimethoprim-sulfamethoxazole in Infants and Children
Started Nov 2015
51 enrolled
Bacterial Infections
Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers
Started Feb 2015
70 enrolled
Anaemia
Daily Trimethoprim-sulfamethoxazole or Weekly Chloroquine Among Adults on ART in Malawi
Started Nov 2012
1,499 enrolled
HIV
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.