NDAINJECTIONINJECTABLEPriority Review
Approved
Sep 1981
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
6
Data completeness
4/8 — Partial
Priority Review
TRIDIL (nitroglycerin) by Pfizer is (no) which activates guanylate cyclase, resulting in an increase of guanosine 3'5' monophosphate (cyclic gmp) in smooth muscle and other tissues. Approved for coronary artery disease, cardiovascular disease, heart failure. First approved in 1981.
Drug data last refreshed 18h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TRIDIL (nitroglycerin) is an injectable nitrate vasodilator approved in 1981 for acute management of coronary artery disease, cardiovascular disease, and heart failure. It works by releasing nitric oxide (NO), which activates guanylate cyclase to increase cyclic GMP in smooth muscle, leading to vasodilatation and reduced cardiac preload and afterload.
LOE Approaching
As a product approaching loss of exclusivity with 43+ years on market, the team is likely focused on defending inpatient hospital formulary positions and managing generic competition rather than growth initiatives.
Mechanism of Action
(NO) which activates guanylate cyclase, resulting in an increase of guanosine 3'5' monophosphate (cyclic GMP) in smooth muscle and other tissues. These events lead to dephosphorylation of myosin light chains, which regulate the contractile state in smooth muscle, and result in vasodilatation.
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.