NDAORALTABLET
Approved
Jul 2010
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
TRIBENZOR (olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide) by Pfizer is regulation. Approved for hypertension, to lower blood pressure. First approved in 2010.
Drug data last refreshed 5h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TRIBENZOR is a fixed-dose triple-combination oral tablet combining olmesartan medoxomil (AT1 receptor blocker), amlodipine besylate (calcium channel blocker), and hydrochlorothiazide (thiazide diuretic) for the treatment of hypertension. It works through three synergistic mechanisms: blocking angiotensin II-mediated vasoconstriction, inhibiting calcium influx into vascular smooth muscle, and promoting sodium/chloride excretion to reduce blood pressure. The combination allows for more potent antihypertensive effect than individual components alone.
$0.002BPart D
LOE ApproachingDeclining
Product approaching loss of exclusivity with minimal commercial investment; team likely focused on transition planning and retention of existing volume rather than growth initiatives.
Mechanism of Action
regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; olmesartan medoxomil blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.