NDAORALTABLET
Approved
Apr 2008
Lifecycle
Post-LOE
Competitive Pressure
35/100
Clinical Trials
20
Data completeness
6/8 — Strong
TREXIMET (sumatriptan succinate and naproxen sodium) by Currax Pharmaceuticals is naproxen. Approved for cluster headache, migraine attacks. First approved in 2008.
Drug data last refreshed 3h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TREXIMET is an oral combination tablet containing sumatriptan succinate (a 5-HT1B/1D receptor agonist) and naproxen sodium (an NSAID), approved in 2008 for acute treatment of migraine attacks and cluster headaches. Sumatriptan causes cranial vessel constriction and inhibits neuropeptide release via trigeminal system modulation, while naproxen reduces prostaglandin-mediated inflammation and pain sensitization. This dual-mechanism approach addresses both the vascular and inflammatory components of migraine pathophysiology.
$0.001BPart D
Post-LOEDeclining
Post-LOEProduct is in post-LOE phase with minimal Part D volume ($1M in 2023, 556 claims), indicating a mature/niche market with likely smaller commercial teams focused on retention and specialty positioning.
Mechanism of Action
naproxen. Sumatriptan binds with high affinity to cloned 5-HT 1B / 1D receptors. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT 1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system,…
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.