NDAORALTABLET, EXTENDED RELEASEPriority Review
Approved
Aug 1984
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
11
Data completeness
3/8 — Basic
Priority Review
TRENTAL (pentoxifylline) by Bausch Health is clinical pharmacology mode of action: pentoxifylline and its metabolites improve the flow properties of blood by decreasing its viscosity. First approved in 1984.
Drug data last refreshed 5h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TRENTAL (pentoxifylline) is an oral small molecule that improves blood flow by decreasing blood viscosity and enhancing erythrocyte flexibility in patients with chronic peripheral arterial disease. It works by modifying leukocyte properties, increasing deformability, and inhibiting neutrophil adhesion to enhance tissue oxygenation. The precise mechanism of clinical improvement is still being defined, though hemorrheologic effects are well-established.
LOE Approaching
As a 40-year-old product approaching loss of exclusivity, the brand team is likely maintaining steady operations with modest resources allocated to retention and lifecycle management strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY Mode of Action: Pentoxifylline and its metabolites improve the flow properties of blood by decreasing its viscosity. In patients with chronic peripheral arterial disease, this increases blood flow to the affected microcirculation and enhances tissue oxygenation. The precise…
Worked on TRENTAL at Bausch Health? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.