TOLSURA

PeakSM

itraconazole

NDAORALCAPSULE
Approved
Dec 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20

Mechanism of Action

Cytochrome P450 3A4 Inhibitors

Pharmacologic Class:

Azole Antifungal

Clinical Trials (5)

NCT07435194Phase 1Not Yet Recruiting

A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)

Started Mar 2026
28 enrolled
Healthy
NCT07308652Phase 1Active Not Recruiting

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 764198 in the Blood

Started Feb 2026
14 enrolled
Healthy
NCT07395024Phase 1Recruiting

A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults

Started Feb 2026
54 enrolled
Healthy Volunteer
NCT07402915Phase 1Recruiting

Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Started Jan 2026
24 enrolled
Fallopian Tube CancerOvarian CancerPrimary Peritoneal
NCT07335419Phase 1Active Not Recruiting

A Study to Learn if Itraconazole Changes How the Body Processes PF-07248144 (Study Medicine)

Started Jan 2026
12 enrolled
Healthy Adult Participants

Loss of Exclusivity

LOE Date
Jun 21, 2033
88 months away
Patent Expiry
Jun 21, 2033

Patent Records (5)

Patent #ExpiryTypeUse Code
10463740
Jun 21, 2033
Product
U-2453
10806792
Jun 21, 2033
Product
8921374
Jun 21, 2033
Product
9272046
Jun 21, 2033
Product
9713642
Jun 21, 2033
U-2453