TOLCAPONE (tolcapone) by Pfizer is mechanism of action: tolcapone is a selective and reversible inhibitor of catechol- o -methyltransferase (comt). Approved for catechol-o-methyltransferase inhibitor [epc]. First approved in 2015.
Drug data last refreshed 1w ago
Mechanism of Action: Tolcapone is a selective and reversible inhibitor of catechol- O -methyltransferase (COMT). In mammals, COMT is distributed throughout various organs. The highest activities are in the liver and kidney. COMT also occurs in the heart, lung, smooth and skeletal muscles,…
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Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR)
A Study Assessing the Safety and Pharmacokinetic Profile of Modified Release Formulations of Tolcapone