NDAORALCAPSULE
Approved
Oct 1999
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
TIKOSYN (dofetilide) by Pfizer is clinical pharmacology mechanism of action dofetilide shows vaughan williams class iii antiarrhythmic activity. First approved in 1999.
Drug data last refreshed 2h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TIKOSYN (dofetilide) is an oral Class III antiarrhythmic agent that selectively blocks the rapid component of the delayed rectifier potassium current (IKr) to prolong cardiac action potential duration and refractory period. It is indicated for the conversion of atrial fibrillation and flutter to normal sinus rhythm and maintenance of normal rhythm in patients with these conditions. The drug works through pure potassium channel blockade without effects on sodium channels or adrenergic receptors.
$0.79MPart D
LOE ApproachingDeclining
Late-stage product with minimal Part D spending ($790K in 2023) signals a contracting market and reduced commercial headcount allocation.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action Dofetilide shows Vaughan Williams Class III antiarrhythmic activity. The mechanism of action is blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, I Kr . At concentrations covering several orders of…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.