NDAINJECTIONINJECTABLE
Approved
Jul 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
3/8 — Basic
TIGAN (trimethobenzamide hydrochloride) by Pfizer is 12. First approved in 1974.
Drug data last refreshed 3h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TIGAN (trimethobenzamide HCl) is a small-molecule antiemetic approved in 1974 that acts on the chemoreceptor trigger zone in the medulla to suppress nausea and vomiting. The mechanism involves inhibition of emetic impulses via the CTZ rather than direct action on the vomiting center. It is available in oral capsule and intramuscular injection formulations for patients requiring rescue antiemetic therapy.
LOE Approaching
As a mature product approaching loss of exclusivity, the brand team is likely small and focused on lifecycle extension or managed decline with limited headcount growth.
Mechanism of Action
12.1 Mechanism of Action The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.