NDAORALTABLETPriority Review
Approved
Oct 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
Priority Review
TICLID (ticlopidine hydrochloride) by Roche is clinical pharmacology mechanism of action when taken orally, ticlopidine hydrochloride causes a time- and dose-dependent inhibition of both platelet aggregation and release of platelet granule constituents, as well as a prolongation of bleeding time. First approved in 1991.
Drug data last refreshed 12h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TICLID (ticlopidine hydrochloride) is an oral antiplatelet agent that inhibits ADP-induced platelet aggregation and prolongs bleeding time through irreversible platelet membrane inhibition. It is used to reduce thrombotic events in patients at risk for stroke, myocardial infarction, or other ischemic complications. The drug achieves maximum platelet inhibition after 8–11 days of twice-daily dosing.
LOE Approaching
Product is approaching loss of exclusivity with limited linked job openings, indicating a contracted or transitional commercial organization focused on managed decline.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action When taken orally, ticlopidine hydrochloride causes a time- and dose-dependent inhibition of both platelet aggregation and release of platelet granule constituents, as well as a prolongation of bleeding time. The intact drug has no significant activity at…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.