TIBSOVO

PeakSM

ivosidenib

NDAORALTABLETPriority Review
Approved
Jul 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
4

Mechanism of Action

Isocitrate Dehydrogenase 1 Inhibitors

Pharmacologic Class:

Isocitrate Dehydrogenase 1 Inhibitor

Clinical Trials (4)

NCT07075016Phase 3Recruiting

Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy

Started Aug 2025
227 enrolled
Acute Myeloid Leukemia
NCT05756777Phase 1Recruiting

A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

Started Jun 2023
36 enrolled
Acute Myeloid Leukemia (AML)
NCT04056910Phase 2Completed

Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors

Started Sep 2021
15 enrolled
Advanced Solid TumorIDH1 MutationGlioma
NCT04088188Phase 1Terminated

Gemcitabine and Cisplatin With Ivosidenib or Pemigatinib for the Treatment of Unresectable or Metastatic Cholangiocarcinoma

Started Jan 2021
8 enrolled
Advanced CholangiocarcinomaMetastatic CholangiocarcinomaUnresectable Cholangiocarcinoma

Loss of Exclusivity

LOE Date
Jun 7, 2039
161 months away
Patent Expiry
Jun 7, 2039
Exclusivity Expiry
Oct 24, 2030

Patent Records (5)

Patent #ExpiryTypeUse Code
10610125
Jun 21, 2030
U-3385
11667673
Jan 18, 2033
U-3742
9850277
Jan 18, 2033
SubstanceProduct
U-3213
10717764
Jan 18, 2033
U-3215
9474779
Aug 19, 2033
SubstanceProduct
U-3213