NDAORALTABLET
Approved
Dec 1988
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
15
Data completeness
4/8 — Partial
THALITONE (chlorthalidone) by R-Pharm US is clinical pharmacology: chlorthalidone is an oral diuretic with prolonged action (48–72 hours) and low toxicity. First approved in 1988.
Drug data last refreshed 8h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
THALITONE (chlorthalidone) is an oral thiazide-like diuretic approved in 1988 for hypertension and edema management. It works by inhibiting sodium and chloride reabsorption in the cortical diluting segment of Henle's loop, producing copious diuresis with a prolonged duration of action (48–72 hours). The drug is approximately equipotent to benzothiadiazine diuretics at maximal therapeutic doses.
$0.538MPart D
LOE ApproachingProduct approaching loss of exclusivity with modest Medicare utilization (3,257 Part D claims in 2023), indicating a niche legacy franchise with limited growth opportunity.
Mechanism of Action
CLINICAL PHARMACOLOGY: Chlorthalidone is an oral diuretic with prolonged action (48–72 hours) and low toxicity. The major portion of the drug is excreted unchanged by the kidneys. The diuretic effect of the drug occurs in approximately 2.6 hours and continues for up to 72 hours. The mean half-life…
Pharmacologic Class:
Thiazide-like Diuretic
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (15)
Effectiveness and Safety of Sequential Triple Combination Therapy (Amlodipine/Losartan/Chlorthalidone) in Korean Patients With Hypertension
Started Mar 2026
3,500 enrolled
Hypertension
Efficacy and Safety of Candesartan Associated With Chlorthalidone Versus Losartan Associated With Hydrochlorothiazide (Hyzaar®) in Essential Hypertension Control
Started Nov 2016
0Essential Arterial Hypertension
Efficacy and Safety of Candesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control
Started Nov 2016
0Essential Arterial Hypertension
S-amlodipine+Chlorthalidone vs S-amlodipine+Telmisartan in Hypertension
Started Dec 2015
170 enrolled
Essential Hypertension
A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone
Started Oct 2011
507 enrolled
Essential Hypertension
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.