NDAORALTABLETPriority Review
Approved
Aug 1959
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
Priority Review
TENUATE (diethylpropion hydrochloride) by Teva is clinical pharmacology diethylpropion hydrochloride is a sympathomimetic amine with some pharmacologic activity similar to that of the prototype drugs of this class used in obesity, the amphetamines. Approved for the management of exogenous obesity, higher. First approved in 1959.
Drug data last refreshed 3d ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TENUATE (diethylpropion hydrochloride) is a sympathomimetic amine oral anorectic used for the management of exogenous obesity. It works by stimulating the central nervous system and elevating blood pressure to reduce appetite, though the exact mechanism of weight loss remains incompletely understood. The drug is rapidly absorbed and extensively metabolized via N-dealkylation and reduction, with active metabolites contributing to therapeutic effect.
LOE Approaching
This legacy product is approaching loss of exclusivity with minimal commercial spending data, suggesting a mature, declining brand with limited headcount and reduced marketing investment.
Mechanism of Action
CLINICAL PHARMACOLOGY Diethylpropion hydrochloride is a sympathomimetic amine with some pharmacologic activity similar to that of the prototype drugs of this class used in obesity, the amphetamines. Actions include some central nervous system stimulation and elevation of blood pressure. Tolerance…
Worked on TENUATE at Teva? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.