NDAORALTABLET
Approved
Oct 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
4
Data completeness
4/8 — Partial
TENEX (guanfacine hydrochloride) by Teva is clinical pharmacology guanfacine tablets, are an orally active antihypertensive agent whose principal mechanism of action appears to be stimulation of central α 2 -adrenergic receptors. First approved in 1986.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TENEX (guanfacine hydrochloride) is an oral antihypertensive agent approved in 1986 that works by stimulating central α2-adrenergic receptors to reduce sympathetic nerve impulses. It decreases peripheral vascular resistance and heart rate, resulting in blood pressure reduction in patients with mild to moderate hypertension. The drug is available as a tablet and can be used as monotherapy or in combination with other antihypertensives like thiazide diuretics.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30%), signaling potential team restructuring and shift toward generic/lifecycle management strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY Guanfacine tablets, are an orally active antihypertensive agent whose principal mechanism of action appears to be stimulation of central α 2 -adrenergic receptors. By stimulating these receptors, guanfacine reduces sympathetic nerve impulses from the vasomotor center to the…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.