NDAORALCAPSULEPriority Review
Approved
Dec 1999
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
13
Data completeness
3/8 — Basic
Priority Review
TARGRETIN (bexarotene) by Bausch + Lomb. Approved for retinoid [epc]. First approved in 1999.
Drug data last refreshed 11h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TARGRETIN (bexarotene) is an oral retinoid capsule approved in 1999 for cutaneous T-cell lymphoma and other retinoid-responsive conditions. It works as a selective retinoid X receptor (RXR) agonist, modulating gene transcription and cellular differentiation. The drug represents a niche oncology/dermatology product with a well-established but aging market presence.
LOE Approaching
As LOE approaches, TARGRETIN teams are shrinking; career growth depends on transition to pipeline assets or defensive generic strategies within Bausch + Lomb's dermatology portfolio.
Mechanism of Action
Pharmacologic Class:
Retinoid
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (13)
A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Participants With CD30-Positive Cutaneous T-Cell Lymphoma (ALCANZA Study)
Started Jun 2012
131 enrolled
Primary Cutaneous Anaplastic Large Cell LymphomaMycosis FungoidesCutaneous T-Cell Lymphoma
Phase I Study of CS-7017 and Bexarotene
Started Dec 2011
9 enrolled
Solid TumorsLymphomaMultiple Myeloma
Pralatrexate and Bexarotene in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma
Started Mar 2010
34 enrolled
Cutaneous T-cell LymphomaMycosis FungoidesSezary Syndrome+1 more
Study Evaluating Two Dose Levels of Targretin Capsules in Participants With Refractory Cutaneous T-Cell Lymphoma (CTCL)
Started Jan 2010
59 enrolled
Refractory Cutaneous T-cell Lymphoma
BATTLE Program: Tarceva and Targretin in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Started Nov 2006
37 enrolled
Lung Cancer
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.