NDAORALTABLETPriority Review
Approved
Jun 1950
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
Priority Review
TAPAZOLE (methimazole) by Pfizer is thyroid hormone synthesis inhibitors [moa]. First approved in 1950.
Drug data last refreshed 17h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TAPAZOLE (methimazole) is an oral small-molecule thyroid hormone synthesis inhibitor used to treat hyperthyroidism by blocking thyroid peroxidase and reducing thyroid hormone production. It is a first-line antithyroid agent indicated for patients with Graves' disease, toxic nodular goiter, and thyroid storm preparation. The drug works by inhibiting the incorporation of iodine into thyroid hormones, effectively lowering circulating T3 and T4 levels.
LOE Approaching
A long-established product approaching loss of exclusivity with moderate competitive pressure (30/100) presents limited growth but stable maintenance opportunities.
Mechanism of Action
Thyroid Hormone Synthesis Inhibitors
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on TAPAZOLE offers stable, lower-risk career roles in maintenance and defensive positioning rather than growth or innovation. With minimal linked job postings and an approaching LOE, career advancement may be limited unless you seek transition to higher-growth franchises within Pfizer.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.