TABRECTA

Peak

capmatinib

NDAORALTABLETPriority Review
Approved
May 2020
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
22

Mechanism of Action

MET, including the mutant variant produced by exon 14 skipping. MET exon 14 skipping results in a protein with a missing regulatory domain that reduces its negative regulation leading to increased downstream MET signaling. Capmatinib inhibited cancer cell growth driven by a mutant MET variant…

Indications (1)

Clinical Trials (5)

NCT06988475Phase 2/3Recruiting

DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations

Started Nov 2024
30 enrolled
Solid TumourHaematological MalignancyMalignant Neoplasm+8 more
NCT05567055Phase 2Withdrawn

Central Nervous System Efficacy of Capmatinib in NSCLC With Brain Metastases With cfDNA Positive MET Alterations

Started Oct 2023
0
Non-small Cell Lung Cancer
NCT05703516N/ARecruiting

A Post Approval Commitment Study on Tabrecta® (Capmatinib) in South Korea

Started Jun 2023
250 enrolled
Non-Small-Cell Lung Carcinoma
NCT05488314Phase 1/2Active Not Recruiting

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

Started Dec 2022
57 enrolled
Carcinoma, Non-Small-Cell Lung
NCT05110196Phase 4Completed

Study of Capmatinib in Indian Patients With MET Exon 14 Skipping Mutation Positive Advanced NSCLC.

Started Sep 2022
50 enrolled
Non-Small Cell Lung Carcinoma

Loss of Exclusivity

LOE Date
Jul 22, 2035
114 months away
Patent Expiry
Jul 22, 2035
Exclusivity Expiry
May 6, 2027

Patent Records (5)

Patent #ExpiryTypeUse Code
12084449
Nov 19, 2027
U-2813
8461330
Nov 19, 2027
SubstanceProduct
8901123
May 20, 2029
U-2813
8420645
Jun 5, 2031
SubstanceProduct
7767675
Nov 19, 2032
SubstanceProduct