NDAVAGINALCREAM
Approved
Nov 2008
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
SYNTHETIC CONJUGATED ESTROGENS A (estrogens, conjugated synthetic a) by Teva is clinical pharmacology endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. First approved in 2008.
Drug data last refreshed 3d ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Synthetic Conjugated Estrogens A is a hormone replacement therapy (HRT) product administered as a vaginal cream containing synthetic conjugated estrogens that mimic endogenous estrogen metabolism. It works by binding to estrogen receptors in target tissues to maintain female reproductive system function and reduce postmenopausal symptoms. The product is indicated for postmenopausal women experiencing estrogen deficiency.
LOE Approaching
Product approaching end-of-life with declining market exclusivity; expect smaller, maintenance-focused brand teams and potential consolidation within HRT portfolios.
Mechanism of Action
CLINICAL PHARMACOLOGY Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.