SULFAMETHOXAZOLE AND TRIMETHOPRIM
LOE ApproachingNDAORALSUSPENSION
Approved
Jan 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
SULFAMETHOXAZOLE AND TRIMETHOPRIM by Teva is clinical pharmacology sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. First approved in 1983.
Drug data last refreshed 8h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sulfamethoxazole and trimethoprim (co-trimoxazole) is a fixed-dose combination antibiotic that inhibits bacterial folate synthesis through dual mechanism: sulfamethoxazole blocks dihydrofolic acid formation, while trimethoprim inhibits dihydrofolate reductase. It is used to treat urinary tract infections, Pneumocystis pneumonia (PCP), and other bacterial infections across pediatric and adult populations.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure; team focus likely shifting toward generic transition planning and cost management.
Mechanism of Action
CLINICAL PHARMACOLOGY Sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. Sulfamethoxazole is metabolized…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.