SULFAMETHOXAZOLE AND TRIMETHOPRIM
LOE ApproachingNDAORALTABLET
Approved
May 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
SULFAMETHOXAZOLE AND TRIMETHOPRIM by Fosun Pharma is clinical pharmacology sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. First approved in 1982.
Drug data last refreshed 18h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sulfamethoxazole and trimethoprim (SMX-TMP) is a fixed-dose combination antibiotic that synergistically inhibits bacterial folate synthesis, making it a broad-spectrum agent effective against gram-positive and gram-negative bacteria. It is used to treat urinary tract infections, Pneumocystis jirovecii pneumonia (PCP), and other serious infections across both immunocompromised and immunocompetent populations. The mechanism relies on sequential blockade of dihydrofolate reductase and dihydropteroate synthase, providing bactericidal activity.
LOE Approaching
Product is in late-stage lifecycle with minimal current job openings, indicating a mature/declining team and cost-management focus rather than growth investment.
Mechanism of Action
CLINICAL PHARMACOLOGY Sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. Sulfamethoxazole is metabolized…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.