SULFAMETHOXAZOLE AND TRIMETHOPRIM
LOE ApproachingNDAORALTABLET
Approved
May 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
SULFAMETHOXAZOLE AND TRIMETHOPRIM by Fosun Pharma is clinical pharmacology sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. First approved in 1982.
Drug data last refreshed 8h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sulfamethoxazole and trimethoprim (SMX-TMP) is a fixed-dose combination antibiotic containing a sulfonamide and dihydrofolate reductase inhibitor that work synergistically to inhibit bacterial folate synthesis. It is indicated for urinary tract infections, Pneumocystis jirovecii pneumonia prophylaxis and treatment, and other bacterial infections. This combination is a classic broad-spectrum agent effective against gram-positive and gram-negative organisms.
LOE Approaching
LOE-approaching lifecycle indicates a mature, defended franchise with moderate competitive pressure (30/100) and likely smaller commercial teams focused on maintenance and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY Sulfamethoxazole and trimethoprim is rapidly absorbed following oral administration. Both sulfamethoxazole and trimethoprim exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form. Sulfamethoxazole is metabolized…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.