NDAINJECTIONINJECTABLE
Approved
Apr 1956
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
2/8 — Basic
Drug data last refreshed 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
SPARINE (promazine hydrochloride) is a first-generation antipsychotic administered by injection, approved in 1956. It treats schizophrenia, psychotic disorders, manic-depressive illness, nausea, vomiting, hiccups, anxiety, acute intermittent porphyria, and tetanus through dopamine antagonism. As a legacy injectable, it occupies a niche in acute psychiatric and symptomatic management.
LOE Approaching
As a legacy product approaching loss of exclusivity with minimal current market presence, SPARINE supports a small, maintenance-focused commercial team focused on institutional and formulary retention rather than growth.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Started Nov 2016
20 enrolled
Anti-PsychoticManagement of Manifestations of Psychotic DisordersTreatment of Schizophrenia+6 more
Career Relevance
Working on SPARINE offers limited career growth due to its legacy status and approaching LOE; roles focus on institutional sales, formulary management, and compliance rather than innovation or market expansion. This position is suitable for professionals seeking stable, maintenance-focused responsibilities in a declining franchise rather than career advancement in a growth product.
Worked on SPARINE at Hikma? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.