SODIUM ZIRCONIUM CYCLOSILICATE

Pre-Launch

sodium zirconium cyclosilicate

AstraZeneca

ANDAPOWDER, FOR SUSPENSION

Lifecycle

Pre-Launch

Clinical Trials

Data completeness

3/8 — Basic

SODIUM ZIRCONIUM CYCLOSILICATE (sodium zirconium cyclosilicate) by AstraZeneca is (sodium zirconium cyclosilicate) is a non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium. Approved for hyperkalemia in adults.

Drug data last refreshed 1mo ago

Mechanism of Action

(sodium zirconium cyclosilicate) is a non-absorbed zirconium silicate that preferentially captures potassium in exchange for hydrogen and sodium. In vitro , LOKELMA has a high affinity for potassium ions, even in the presence of other cations such as calcium and magnesium. LOKELMA increases fecal…

Indications (1)

hyperkalemia in adults

Clinical Trials (17)

NCT06635499N/ACompleted

VITALIZE.Use and Effectiveness of Sodium Zirconium Cyclosilicate (LokelmaTM) in the Real-world Setting in Spain

Started Nov 2024

232 enrolled

Hyperkalaemia

NCT06365684Phase 4Unknown

Sodium Zirconium Cyclosilicate to Allow Liberal Fruit and Vegetable Intake for Patients With CKD Stage 3b and 4

Started Apr 2024

16 enrolled

HyperkalemiaDiet ModificationChronic Kidney Disease+1 more

NCT06185660N/ACompleted

A National, Multicenter, Prospective, Observational Study to Assess Patient Characteristics, Treatment Algorithms and Disease Management of Hyperkalaemia Patients With Chronic Kidney Disease or Under Dialysis or With Heart Failure, Treated With Sodium Zirconium Cyclosilicate in Greece

Started Feb 2024

125 enrolled

Hyperkalaemia

NCT05347693Phase 4Completed

Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge Study

Started Mar 2022

186 enrolled

HyperkalaemiaChronic Kidney Disease

NCT05271266N/ACompleted

A Multicenter, Prospective, Non-interventional Cohort Study to Evaluate the Safety and Treatment Pattern of Sodium Zirconium Cyclosilicate for Hyperkalaemia Management in Real World Practice in China

Started Mar 2022

1,000 enrolled

Hyperkalaemia

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.