SODIUM PHENYLACETATE AND SODIUM BENZOATE
Peaksodium phenylacetate and sodium benzoate
NDAINTRAVENOUSSOLUTION
Approved
Jun 2021
Lifecycle
Peak
Competitive Pressure
30/100
Data completeness
2/8 — Basic
SODIUM PHENYLACETATE AND SODIUM BENZOATE (sodium phenylacetate and sodium benzoate) by MAIA Biotechnology is enzymes: n -acetylglutamate synthetase (nags), carbamyl phosphate synthetase (cps), argininosuccinate synthetase (ass), ornithine transcarbamylase (otc), argininosuccinate lyase (asl), or arginase (arg). First approved in 2021.
Drug data last refreshed 5h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sodium phenylacetate and sodium benzoate is an intravenous solution that provides an alternative nitrogen disposal pathway for patients with urea cycle disorders by conjugating with glutamine and glycine to form excretable metabolites. The drug bypasses defective enzymes in the urea cycle (NAGS, CPS, OTC, ASS, ASL, ARG) by enabling waste nitrogen removal through phenylacetylglutamine and hippuric acid excretion. It is indicated for hyperammonemia in patients with deficiencies in any of the six urea cycle enzymes.
Peak
Product is in peak commercial phase post-approval with moderate competitive pressure (30/100), suggesting active but stabilizing market demand and team investments in market expansion.
Mechanism of Action
enzymes: N -acetylglutamate synthetase (NAGS), carbamyl phosphate synthetase (CPS), argininosuccinate synthetase (ASS), ornithine transcarbamylase (OTC), argininosuccinate lyase (ASL), or arginase (ARG). Sodium phenylacetate and sodium benzoate are metabolically active compounds that can serve as…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.