SODIUM PHENYLACETATE AND SODIUM BENZOATE
Peaksodium phenylacetate and sodium benzoate
NDAINTRAVENOUSSOLUTION
Approved
Jun 2021
Lifecycle
Peak
Competitive Pressure
30/100
Data completeness
2/8 — Basic
SODIUM PHENYLACETATE AND SODIUM BENZOATE (sodium phenylacetate and sodium benzoate) by MAIA Biotechnology is enzymes: n -acetylglutamate synthetase (nags), carbamyl phosphate synthetase (cps), argininosuccinate synthetase (ass), ornithine transcarbamylase (otc), argininosuccinate lyase (asl), or arginase (arg). First approved in 2021.
Drug data last refreshed 21h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sodium phenylacetate and sodium benzoate is an intravenous solution that provides an alternative nitrogen disposal pathway for patients with urea cycle disorders who lack functional enzymes in the ammonia detoxification pathway. The drug works by conjugating phenylacetate with glutamine and benzoate with glycine to form excretable metabolites (phenylacetylglutamine and hippuric acid) that bypass the defective urea cycle. This mechanism effectively reduces ammonia levels and prevents hyperammonemia-related neurotoxicity in patients with various urea cycle enzyme deficiencies.
Peak
Product is at peak lifecycle stage with moderate competitive pressure (30%), suggesting stable commercial team and potential focus on market penetration in rare disease setting.
Mechanism of Action
enzymes: N -acetylglutamate synthetase (NAGS), carbamyl phosphate synthetase (CPS), argininosuccinate synthetase (ASS), ornithine transcarbamylase (OTC), argininosuccinate lyase (ASL), or arginase (ARG). Sodium phenylacetate and sodium benzoate are metabolically active compounds that can serve as…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.