NDAINJECTIONINJECTABLE
Approved
Jul 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
SODIUM NITROPRUSSIDE (sodium nitroprusside) by Baxter International is clinical pharmacology the principal pharmacological action of sodium nitroprusside is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Approved for acute congestive heart failure. First approved in 1982.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sodium nitroprusside is a rapid-acting vasodilator administered intravenously that relaxes vascular smooth muscle in both arteries and veins. It is indicated for acute congestive heart failure and hypertensive crises, working by reducing preload and afterload through peripheral vasodilation with a circulatory half-life of approximately 2 minutes.
LOE Approaching
As a legacy product approaching loss of exclusivity, the brand team is likely small and focused on defending market position against established generic and branded competitors in the acute care segment.
Mechanism of Action
CLINICAL PHARMACOLOGY The principal pharmacological action of sodium nitroprusside is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Other smooth muscle (e.g., uterus, duodenum) is not affected. Sodium nitroprusside is more active on veins than on…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.