NDAINJECTIONINJECTABLE
Approved
Jul 1982
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
SODIUM NITROPRUSSIDE (sodium nitroprusside) by Baxter is clinical pharmacology the principal pharmacological action of sodium nitroprusside is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Approved for acute congestive heart failure. First approved in 1982.
Drug data last refreshed 9h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Sodium nitroprusside is a direct-acting vasodilator administered intravenously that relaxes vascular smooth muscle in both arteries and veins. It is indicated for acute congestive heart failure and hypertensive crisis, working by reducing preload and afterload through rapid peripheral vasodilation. The drug has a 2-minute circulatory half-life and produces hemodynamic effects within 1–2 minutes of infusion initiation.
LOE Approaching
Product approaching loss of exclusivity with modest competitive pressure (30%), indicating potential team consolidation and shift toward lifecycle extension or generic defense strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY The principal pharmacological action of sodium nitroprusside is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Other smooth muscle (e.g., uterus, duodenum) is not affected. Sodium nitroprusside is more active on veins than on…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.