SIMBRINZA

Peak

brinzolamide/brimonidine tartrate

NDAOPHTHALMICSUSPENSION/DROPS
Approved
Apr 2013
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
8

Mechanism of Action

Carbonic Anhydrase Inhibitors

Pharmacologic Class:

Carbonic Anhydrase Inhibitor

Clinical Trials (5)

NCT02730871Phase 4Terminated

Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®

Started Jun 2016
173 enrolled
Open-angle GlaucomaOcular Hypertension
NCT02770248Phase 4Completed

24-hr Intraocular Pressure Control With SIMBRINZA ®

Started May 2016
162 enrolled
Glaucoma
NCT02419508Phase 4Completed

SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA)

Started Aug 2015
290 enrolled
Open-Angle GlaucomaOcular Hypertension
NCT02348476N/ACompleted

A Study of Simbrinza™ Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension

Started Nov 2014
150 enrolled
Open-Angle GlaucomaOcular Hypertension
NCT02167035Phase 4Completed

Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)

Started Aug 2014
43 enrolled
GlaucomaOcular Hypertension

Loss of Exclusivity

LOE Date
Oct 30, 2030
56 months away
Patent Expiry
Oct 30, 2030

Patent Records (2)

Patent #ExpiryTypeUse Code
9421265
Jun 17, 2030
Product
9044484
Oct 30, 2030
Product