SIKLOS

Peak

hydroxyurea

NDAORALTABLET
Approved
Dec 2017
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

Pharmacologic Class:

Antimetabolite

Clinical Trials (5)

NCT06456346Phase 3Recruiting

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Started Jul 2024
300 enrolled
Essential Thrombocythemia
NCT06079879Phase 3Recruiting

A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)

Started Dec 2023
340 enrolled
Essential Thrombocythemia
NCT05285917Phase 3Recruiting

Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa

Started Nov 2023
400 enrolled
Sickle Cell Anemia in ChildrenSickle Cell Disease
NCT05421104N/ACompleted

Ruxolitinib for Polycythemia Vera in Patients Resistant to or Intolerant of Hydroxyurea.

Started Nov 2020
1,576 enrolled
Polycythemia Vera (PV)
NCT04285086Phase 3Active Not Recruiting

Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance

Started Aug 2020
174 enrolled
Essential Thrombocythemia