SEREVENT
LOE ApproachingNDAINHALATIONAEROSOL, METEREDPriority Review
Approved
Feb 1994
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
8
Data completeness
4/8 — Partial
Priority Review
SEREVENT by GSK is laba. Approved for asthma, the prevention of bronchospasm only, older with reversible obstructive airway disease and 3 more indications. First approved in 1994.
Drug data last refreshed 11h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
SEREVENT (salmeterol) is a long-acting beta-2 agonist (LABA) inhaled as a metered-dose aerosol for maintenance treatment of asthma and chronic obstructive pulmonary disease. It works by stimulating beta-2 adrenoceptors in bronchial smooth muscle, increasing cyclic AMP levels to produce sustained bronchodilation and inhibit inflammatory mediator release from mast cells. The drug is indicated for asthma prevention, exercise-induced bronchospasm, and nocturnal asthma symptoms in patients aged 4 years and older.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30/100), signaling potential contraction of brand team size and shift toward generic management or portfolio optimization.
Mechanism of Action
LABA. In vitro studies show salmeterol to be at least 50 times more selective for beta 2 -adrenoceptors than albuterol. Although beta 2 -adrenoceptors are the predominant adrenergic receptors in bronchial smooth muscle and beta 1 -adrenoceptors are the predominant receptors in the heart, there are…
Indications (6)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.