RYBREVANT FASPRO
LaunchBsAbBLASINGLE-USEVIAL
Approved
Feb 2026
Lifecycle
Launch
Competitive Pressure
30/100
Data completeness
4/8 — Partial
RYBREVANT FASPRO by Johnson & Johnson is met. Approved for metastatic nsclc with egfr exon 19 deletions, exon 21 l858r substitution mutations, whose disease has progressed on and 1 more indications. First approved in 2026.
Drug data last refreshed 15h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
RYBREVANT FASPRO is a bispecific antibody (amivantamab) combined with hyaluronidase for subcutaneous administration, designed to treat metastatic non-small cell lung cancer (NSCLC) with EGFR mutations. It works by simultaneously blocking EGFR and MET signaling, degrading these receptors on tumor cells, and recruiting immune effector cells (ADCC and trogocytosis) to destroy cancer cells. The hyaluronidase component enables rapid subcutaneous delivery by temporarily increasing tissue permeability.
Launch
Early-stage launch with moderate competitive pressure (30/100); substantial opportunity to establish market position in EGFR-mutant NSCLC segment.
Mechanism of Action
MET. In in vitro and in vivo studies, amivantamab was able to disrupt EGFR and MET signaling functions through blocking ligand binding and, in exon 19 deletions, exon 21 L858R substitutions, and exon 20 insertion mutation models, degradation of EGFR and MET. The presence of EGFR and MET on the…
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.