NDAORALTABLET
Approved
Jul 2016
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
5
Data completeness
5/8 — Partial
RELISTOR (methylnaltrexone bromide) by Salix Pharmaceuticals is mu-opioid receptor. Approved for opioid-induced constipation (oic) in adults with chronic non-cancer pain, including patients with chronic pain related to prior cancer, its treatment and 4 more indications. First approved in 2016.
Drug data last refreshed 5h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
RELISTOR (methylnaltrexone bromide) is an oral small-molecule peripheral mu-opioid receptor antagonist approved to treat opioid-induced constipation (OIC) in adults with chronic non-cancer pain and advanced illness. As a quaternary amine, it blocks opioid effects in the gastrointestinal tract while preserving central analgesic benefit, making it a targeted solution for a common opioid side effect.
Peak4.5 years to LOE
Product is at peak commercial maturity with 4.5 years of patent protection remaining; team is likely stable or optimizing efficiency ahead of competitive and generic pressure.
Mechanism of Action
mu-opioid receptor. As a quaternary amine, the ability of methylnaltrexone to cross the blood-brain barrier is restricted. This allows methylnaltrexone to function as a peripherally-acting mu-opioid receptor antagonist in tissues such as the gastrointestinal tract, thereby decreasing the…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.