NDAORALSOLUTION
Approved
Mar 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
REGLAN (metoclopramide hydrochloride) by Pfizer is clinical pharmacology metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. First approved in 1983.
Drug data last refreshed 59m ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
REGLAN (metoclopramide HCl) is an oral dopamine antagonist that enhances upper GI motility and prevents nausea by blocking central and peripheral dopamine receptors. It accelerates gastric emptying, increases lower esophageal sphincter pressure, and is used to treat gastroesophageal reflux, diabetic gastroparesis, and chemotherapy-induced nausea. The drug sensitizes GI tissues to acetylcholine without stimulating secretions from gastric, biliary, or pancreatic tissues.
$0.088BPart D
LOE ApproachingProduct faces imminent loss of exclusivity with limited Part D market activity, signaling a transition team focused on lifecycle management rather than growth expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Its mode of action is unclear. It seems to sensitize tissues to the action of acetylcholine. The effect of metoclopramide on motility is not…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.