NDAORALSOLUTION
Approved
Mar 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
REGLAN (metoclopramide hydrochloride) by Pfizer is clinical pharmacology metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. First approved in 1983.
Drug data last refreshed 8h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Reglan (metoclopramide hydrochloride) is a small-molecule dopamine antagonist that enhances upper gastrointestinal motility and provides antiemetic effects by blocking central and peripheral dopamine receptors. It is indicated for gastroesophageal reflux disease, diabetic gastroparesis, and chemotherapy-induced nausea and vomiting, working by sensitizing GI tissues to acetylcholine and accelerating gastric emptying. The drug has been a clinical standard since 1983, with well-characterized pharmacology but emerging safety concerns limiting long-term use.
$0.088MPart D
LOE ApproachingProduct is in late-stage lifecycle with minimal Medicare utilization, signaling small commercial team focused on legacy market management and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Its mode of action is unclear. It seems to sensitize tissues to the action of acetylcholine. The effect of metoclopramide on motility is not…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.