PROVOCHOLINE
LOE Approachingmethacholine chloride
NDAINHALATIONFOR SOLUTIONPriority Review
Approved
Oct 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
2/8 — Basic
Priority Review
Drug data last refreshed 16h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PROVOCHOLINE (methacholine chloride) is an inhalation solution used as a diagnostic agent in bronchial challenge testing to assess airway hyperresponsiveness in patients with suspected asthma. It works by directly stimulating muscarinic receptors on airway smooth muscle, causing bronchoconstriction that helps clinicians identify reactive airway disease. This is a diagnostic tool rather than a therapeutic agent.
LOE Approaching
With LOE approaching on a decades-old diagnostic product, commercial teams are transitioning to defensive positioning and cost optimization rather than growth initiatives.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (3)
Bioequivalence Study of Methacholine Chloride
Started Jan 2024
20 enrolled
Healthy People
A Study to Evaluate Efficacy and Safety of Methacholine Chloride Challenge Test in Diagnosis of Adult Asthma
Started Apr 2014
Asthma
Study of Methacholine Chloride Inhalation Challenge in Children With Bronchial Asthma
Started Feb 2014
10 enrolled
Asthma
Career Relevance
PROVOCHOLINE offers limited growth career opportunities due to its mature, diagnostic-only positioning and approaching LOE. Roles on this product emphasize regulatory compliance, operational efficiency, and maintaining market access rather than commercial expansion or clinical innovation.
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.