Data completeness
2/8 — Basic
PROTAMINE SULFATE (protamine sulfate) by Pfizer is clinical pharmacology: when administered alone, protamine has an anticoagulant effect. Approved for the treatment of heparin overdosage.
Drug data last refreshed 2w ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Protamine sulfate is an intravenous powder antidote that rapidly neutralizes heparin anticoagulation by forming a stable salt complex, reversing heparin's anticoagulant effects within five minutes. It is indicated for the treatment of heparin overdosage in acute clinical settings. The mechanism relies on the ionic interaction between protamine's positive charge and heparin's negative charge to inactivate both drugs simultaneously.
Pre-Launch
As a pre-launch asset from Pfizer, this product represents a foundational opportunity for teams building market infrastructure in the acute care reversal agent category.
Mechanism of Action
CLINICAL PHARMACOLOGY: When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed and the anticoagulant activity of both drugs is lost. Protamine sulfate has a rapid onset of action.…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.