Data completeness
2/8 — Basic
PROTAMINE SULFATE (protamine sulfate) by Pfizer is clinical pharmacology: when administered alone, protamine has an anticoagulant effect. Approved for the treatment of heparin overdosage.
Drug data last refreshed 4h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Protamine sulfate is an intravenous powder antidote that rapidly neutralizes heparin overdosage by forming a stable, inactive salt complex. It works by binding to the strongly acidic heparin molecule, eliminating the anticoagulant activity of both drugs within five minutes of administration. This product is indicated solely for the emergency treatment of heparin toxicity in acute care settings.
Pre-Launch
As a pre-launch product from Pfizer, this represents an early-stage opportunity with limited commercial infrastructure; team buildout and launch planning roles may be available.
Mechanism of Action
CLINICAL PHARMACOLOGY: When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed and the anticoagulant activity of both drugs is lost. Protamine sulfate has a rapid onset of action.…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.