NDAORALTABLET
Approved
Jul 1947
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
PROPYLTHIOURACIL (propylthiouracil) by Pfizer is thyroid hormone synthesis inhibitors [moa]. First approved in 1947.
Drug data last refreshed 1h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Propylthiouracil (PTU) is an oral small-molecule thyroid hormone synthesis inhibitor used to treat hyperthyroidism and Graves' disease. It works by blocking thyroid peroxidase, preventing the formation of thyroid hormones T3 and T4. PTU is particularly valuable in early pregnancy and thyroid storm due to its additional inhibition of peripheral conversion of T4 to T3.
LOE Approaching
As an approaching LOE product with moderate competitive pressure (30%), the team is likely focused on lifecycle extension, patient retention, and efficient operations rather than growth investment.
Mechanism of Action
Thyroid Hormone Synthesis Inhibitors
Pharmacologic Class:
Thyroid Hormone Synthesis Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on PTU offers limited career growth potential given its mature, LOE-approaching lifecycle and minimal linked job openings. Roles are primarily operational and maintenance-focused, suited for professionals seeking stability in a niche therapeutic area rather than growth or innovation experience.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.