NDAORALTABLET
Approved
Feb 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
PRONESTYL (procainamide hydrochloride) by Bristol Myers Squibb is clinical pharmacology procainamide (pa) increases the effective refractory period of the atria, and to a lesser extent the bundle of his-purkinje system and ventricles of the heart. Approved for documented ventricular arrhythmias, such, that and 1 more indications. First approved in 1974.
Drug data last refreshed 2d ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PRONESTYL (procainamide hydrochloride) is a Class IA antiarrhythmic agent indicated for documented ventricular arrhythmias. It works by increasing the effective refractory period of cardiac tissue, reducing conduction velocity, and decreasing automaticity in ectopic pacemaker sites. The drug is administered orally as a tablet and reaches therapeutic plasma levels within 90-120 minutes.
LOE Approaching
PRONESTYL is in late-stage decline with LOE imminent, signaling reduced commercial investment and smaller, legacy-focused brand teams focused on managed care and continuity.
Mechanism of Action
CLINICAL PHARMACOLOGY Procainamide (PA) increases the effective refractory period of the atria, and to a lesser extent the bundle of His-Purkinje system and ventricles of the heart. It reduces impulse conduction velocity in the atria, His-Purkinje fibers, and ventricular muscle, but has variable…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.