NDAORALCAPSULEPriority Review
Approved
May 1976
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
4
Data completeness
4/8 — Partial
Priority Review
PROGLYCEM (diazoxide) by Teva is clinical pharmacology diazoxide produces a dose-related increase in blood glucose, due primarily to an inhibition of insulin release from the pancreas, and also to an extrapancreatic effect. First approved in 1976.
Drug data last refreshed 2d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PROGLYCEM (diazoxide) is an oral small-molecule hyperglycemic agent that inhibits pancreatic insulin release and reduces sodium/water excretion. It is primarily indicated for managing hypoglycemia in gastroenteropancreatic neuroendocrine tumors and has secondary indications in hypertriglyceridemia, dyslipidemia, and obesity. The drug's mechanism relies on suppressing insulin secretion and modulating electrolyte metabolism.
$206KPart D
LOE ApproachingDeclining
Minimal commercial momentum with only $206K in Part D spending signals a legacy product in terminal decline, requiring small, specialized teams focused on niche patient populations.
Mechanism of Action
CLINICAL PHARMACOLOGY Diazoxide produces a dose-related increase in blood glucose, due primarily to an inhibition of insulin release from the pancreas, and also to an extrapancreatic effect. The hyperglycemic effect of diazoxide begins within an hour and generally lasts no more than eight hours in…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.