PROGESTERONE
LOE ApproachingNDAINJECTIONINJECTABLE
Approved
Nov 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
PROGESTERONE by Eli Lilly and Company is ovary, placenta, and adrenal gland. First approved in 1974.
Drug data last refreshed 1m ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Progesterone is an oral micronized progesterone capsule chemically identical to naturally occurring ovarian progesterone, designed to increase bioavailability through micronization technology. It is indicated for use in hormone replacement therapy, typically in combination with conjugated estrogens for postmenopausal women with an intact uterus. The drug works by mimicking endogenous progesterone to provide therapeutic hormone replacement and endometrial protection.
LOE Approaching
Product approaching loss of exclusivity with limited linked job openings (2 positions), indicating a mature, stable franchise with focused clinical staffing needs.
Mechanism of Action
ovary, placenta, and adrenal gland. In the presence of adequate estrogen, progesterone transforms a proliferative endometrium into a secretory endometrium. Progesterone is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo is implanted, progesterone acts to…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Individualized Prolonged Luteal Support After Fresh Embryo Transfer in Women With Low Progesterone
Started Mar 2027
214 enrolled
PregnancyProgesterone SupplementationLow Serum Progesterone
Comparing the Pharmacokinetics of a Progesterone Ring Versus a Progesterone Vaginal Insert
Started Sep 2026
60 enrolled
Pre Term Birth
Exogenous Progesterone as Ovulation Trigger
Started Jul 2026
10 enrolled
OvulationOvarian FunctionAssisted Reproductive Treatments+2 more
Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer
Started Nov 2024
400 enrolled
Frozen Embryo Transfer (FET)InfertilityArtificial Cycle+1 more
PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer
Started Oct 2024
10 enrolled
Endometrial CancerEndometrioid CarcinomaMismatch Repair Deficiency
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.