NDAORALTABLET
Approved
Feb 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
1/8 — Limited
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PRINZIDE is a fixed-dose combination tablet containing hydrochlorothiazide (a thiazide diuretic) and lisinopril (an ACE inhibitor), approved in 1989 for hypertension management. The combination works synergistically to reduce blood pressure through complementary mechanisms: lisinopril inhibits angiotensin II production while hydrochlorothiazide promotes sodium and water excretion. This dual-action formulation improves patient compliance by reducing pill burden.
LOE Approaching
As a mature product approaching loss of exclusivity with moderate competitive pressure (30/100), the brand team likely emphasizes cost-containment and generic transition planning rather than growth initiatives.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on PRINZIDE offers limited career growth opportunity given its LOE-approaching status and zero linked job openings. This assignment is best suited for professionals with strong cost-management, generic transition, or operational expertise who can add value during the product lifecycle's decline phase. Career advancement would typically require transition to higher-growth franchises within the company.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.