NDAORALTABLETPriority Review
Approved
Jun 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
Priority Review
Drug Shortage Active
PRIFTIN is currently in shortage. Reason: Available. This may impact manufacturing, supply chain, and quality hiring at the manufacturer.
PRIFTIN (rifapentine) by Sanofi. Approved for rifamycin antimycobacterial [epc]. First approved in 1998.
Drug data last refreshed 7h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PRIFTIN (rifapentine) is an oral rifamycin antimycobacterial agent approved in 1998 for the treatment of tuberculosis. It is a small-molecule antibiotic that inhibits bacterial RNA polymerase, disrupting mycobacterial gene expression. This product represents a standard-of-care option in TB therapy regimens.
$0.42MPart D
LOE ApproachingProduct is in mature/declining phase with modest Part D claims volume (~2,200 annually), suggesting a small, stable commercial footprint with limited team expansion opportunities.
Mechanism of Action
Pharmacologic Class:
Rifamycin Antimycobacterial
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV
Started Jul 2026
144 enrolled
Tuberculosis
Rifapentine-Based Shorter Regimens for Tuberculosis and TB Infection in Kazakhstan
Started Jul 2026
350 enrolled
TuberculosisTuberculosis Infection, LatentTuberculosis, Pulmonary, Drug Sensitive
Pharmacokinetics and Safety of Double-dose Dolutegravir When Used With Rifapentine for HIV-associated Tuberculosis
Started Feb 2024
30 enrolled
HIV-associated Tuberculosis
Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV
Started Jan 2024
252 enrolled
HIV SeropositivityPregnancyTuberculosis Infection
Comparing Treatment Completion Of Daily Rifapentine & Isoniazid For One Month (1HP) To Weekly High Dose Rifapentine & Isoniazid For 3 Months (3HP) In Persons Living With HIV and in Household Contacts of Recently Diagnosed Tuberculosis Patients
Started Jul 2023
1,000 enrolled
HIV SeropositivityTuberculosisHousehold Contact
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.