NDAORALTABLET
Approved
Mar 2021
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
3
Data completeness
6/8 — Strong
PONVORY (ponesimod) by Vanda Pharmaceuticals is sphingosine 1-phosphate receptor modulators [moa]. Approved for moderate-to-severe chronic plaque psoriasis. First approved in 2021.
Drug data last refreshed 22h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PONVORY (ponesimod) is an oral sphingosine 1-phosphate receptor modulator approved by the FDA on March 18, 2021. It is indicated for the treatment of relapsing forms of multiple sclerosis. The drug works by modulating S1P receptors to reduce lymphocyte egress from lymphoid tissues, thereby decreasing immune cell infiltration into the central nervous system. PONVORY represents an important oral alternative in the MS treatment landscape, offering patients a convenient once-daily dosing option.
$0.0BPart D
16.4 years to LOEMechanism of Action
Sphingosine 1-Phosphate Receptor Modulators
Pharmacologic Class:
Sphingosine 1-phosphate Receptor Modulator
Indications (1)
Clinical Trials (3)
Open Label Study to Investigate the Safety and Efficacy of Ponesimod in Moderate-to-Severe Chronic Plaque Psoriasis
Started Jan 2026
300 enrolled
Moderate-to-severe Chronic Plaque Psoriasis
A Study of Ponesimod in Healthy Adult Participants
Started Oct 2022
28 enrolled
Healthy
A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State
Started Mar 2019
52 enrolled
Healthy
Worked on PONVORY at Vanda Pharmaceuticals? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.