NDATOPICALCREAM
Approved
Jun 2006
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
2
Data completeness
4/8 — Partial
PLIAGLIS (lidocaine and tetracaine) by Crescita Therapeutics is amide-type local anesthetic agent and tetracaine is an ester-type local anesthetic agent. First approved in 2006.
Drug data last refreshed 8h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PLIAGLIS is a topical cream combining lidocaine (amide) and tetracaine (ester) local anesthetics that block sodium ion channels to provide dermal analgesia. Applied directly to intact skin via a peel-off formulation, it delivers rapid localized pain relief without systemic absorption. The dual-agent approach enhances onset and duration of anesthesia for dermatological and minor surgical procedures.
Peak4.4 years to LOE
Product is in peak commercial phase with mature market presence; team size likely stable to modest, focusing on market maintenance rather than expansion.
Mechanism of Action
amide-type local anesthetic agent and tetracaine is an ester-type local anesthetic agent. Both lidocaine and tetracaine block sodium ion channels required for the initiation and conduction of neuronal impulses which, in certain instances, results in local anesthesia. When applied to intact skin,…
Pharmacologic Class:
Amide Local Anesthetic
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
A Non-interventional Study to Evaluate the Use of Pliaglis in Daily Practice
Started Feb 2013
582 enrolled
Health Knowledge, Attitudes, Practice
Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Started Jul 2008
51 enrolled
Nasolabial Folds
Why This Matters for Your Career
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.