PLENVU
Peakpolyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, sodium ascorbate
NDAORALFOR SOLUTION
Approved
May 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
4
Data completeness
5/8 — Partial
PLENVU (polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, sodium ascorbate) by Salix Pharmaceuticals is (peg 3350 plus sodium sulfate components in dose 1, and sodium ascorbate and ascorbic acid plus peg 3350 components in dose 2) which induce the laxative effect. First approved in 2018.
Drug data last refreshed 20h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PLENVU is an oral bowel cleansing solution containing polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, and sodium ascorbate, administered in two doses. It is indicated for bowel preparation prior to colonoscopy and other gastrointestinal procedures. The product works through a dual-dose mechanism where Dose 1 (PEG 3350 plus sodium sulfate) and Dose 2 (sodium ascorbate and ascorbic acid plus PEG 3350) induce laxative effects by increasing water retention in the colon, resulting in loose stools and complete bowel evacuation. PLENVU represents an optimized formulation in the bowel preparation market, competing with other polyethylene glycol-based and alternative cleansing agents.
$0.0BPart D
7.4 years to LOEMechanism of Action
(PEG 3350 plus sodium sulfate components in Dose 1, and sodium ascorbate and ascorbic acid plus PEG 3350 components in Dose 2) which induce the laxative effect. The physiological consequence is increased water retention in the lumen of the colon, resulting in loose stools.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (4)
A Study to Investigate Bowel Cleansing With PLENVU® Compared to Sodium Picosulfate in Participants Aged 1 to < 18 Years of Age in Preparation for Colonoscopy
Started Dec 2025
212 enrolled
Bowel Cleansing Prior to Clinical Procedures
A Study to Investigate the Effect of a Meal At 6pm the Day Before the Colonoscopy on the Bowel Cleansing with Plenvu
Started Feb 2023
525 enrolled
Bowel PreparationBowel Preparation for ColonoscopyBowel Cleansing for Colonoscopy+1 more
A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy
Started Oct 2022
400 enrolled
Colon Disease
A Pharmacokinetic Study of PLENVU® in Healthy Subjects
Started Sep 2020
19 enrolled
Pharmacokinetic
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.