PLENVU
Peakpolyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, sodium ascorbate
NDAORALFOR SOLUTION
Approved
May 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
4
Data completeness
5/8 — Partial
PLENVU (polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, sodium ascorbate) by Salix Pharmaceuticals is (peg 3350 plus sodium sulfate components in dose 1, and sodium ascorbate and ascorbic acid plus peg 3350 components in dose 2) which induce the laxative effect. First approved in 2018.
Drug data last refreshed 17h ago · AI intelligence enriched 20h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PLENVU is a polyethylene glycol (PEG)-based bowel cleansing agent indicated for colon preparation prior to colonoscopy. It combines PEG 3350 with sodium sulfate in the first dose and ascorbic acid components in the second dose to induce osmotic laxation. The drug works by increasing water retention in the colon lumen, producing loose stools for effective bowel cleansing.
$8.0MPart D
Peak7.1 years to LOEPLENVU is at peak lifecycle with modest Part D penetration (~58K claims), indicating a niche but established position in the GI prep market with likely stable-to-small commercial teams.
Mechanism of Action
(PEG 3350 plus sodium sulfate components in Dose 1, and sodium ascorbate and ascorbic acid plus PEG 3350 components in Dose 2) which induce the laxative effect. The physiological consequence is increased water retention in the lumen of the colon, resulting in loose stools.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (4)
A Study to Investigate Bowel Cleansing With PLENVU® Compared to Sodium Picosulfate in Participants Aged 1 to < 18 Years of Age in Preparation for Colonoscopy
Started Dec 2025
212 enrolled
Bowel Cleansing Prior to Clinical Procedures
A Study to Investigate the Effect of a Meal At 6pm the Day Before the Colonoscopy on the Bowel Cleansing with Plenvu
Started Feb 2023
525 enrolled
Bowel PreparationBowel Preparation for ColonoscopyBowel Cleansing for Colonoscopy+1 more
A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy
Started Oct 2022
400 enrolled
Colon Disease
A Pharmacokinetic Study of PLENVU® in Healthy Subjects
Started Sep 2020
19 enrolled
Pharmacokinetic
Worked on PLENVU at Salix Pharmaceuticals? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.