PLENVU
Peakpolyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, sodium ascorbate
NDAORALFOR SOLUTION
Approved
May 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
4
Data completeness
5/8 — Partial
PLENVU (polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, sodium ascorbate) by Salix Pharmaceuticals is (peg 3350 plus sodium sulfate components in dose 1, and sodium ascorbate and ascorbic acid plus peg 3350 components in dose 2) which induce the laxative effect. First approved in 2018.
Drug data last refreshed 33m ago · AI intelligence enriched 33m ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PLENVU is a bowel cleansing agent containing polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, ascorbic acid, and sodium ascorbate delivered as an oral solution. It works by inducing a laxative effect through increased water retention in the colon lumen, resulting in loose stools for colonoscopy preparation. The two-dose formulation is designed to improve patient tolerability compared to single-dose alternatives.
$8MPart D
PeakStable
7.2 years to LOEProduct is in peak commercial phase with modest Medicare Part D utilization; brand team is likely focused on maintaining market position in a mature segment with limited growth upside.
Mechanism of Action
(PEG 3350 plus sodium sulfate components in Dose 1, and sodium ascorbate and ascorbic acid plus PEG 3350 components in Dose 2) which induce the laxative effect. The physiological consequence is increased water retention in the lumen of the colon, resulting in loose stools.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (4)
A Study to Investigate Bowel Cleansing With PLENVU® Compared to Sodium Picosulfate in Participants Aged 1 to < 18 Years of Age in Preparation for Colonoscopy
Started Dec 2025
212 enrolled
Bowel Cleansing Prior to Clinical Procedures
A Study to Investigate the Effect of a Meal At 6pm the Day Before the Colonoscopy on the Bowel Cleansing with Plenvu
Started Feb 2023
525 enrolled
Bowel PreparationBowel Preparation for ColonoscopyBowel Cleansing for Colonoscopy+1 more
A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy
Started Oct 2022
400 enrolled
Colon Disease
A Pharmacokinetic Study of PLENVU® in Healthy Subjects
Started Sep 2020
19 enrolled
Pharmacokinetic
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.