NDAInjectionInjectablePriority Review
Approved
Aug 2003
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
Priority Review
PHOTOFRIN (porfimer sodium) by Lavipharm is 12. First approved in 2003.
Drug data last refreshed 13h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PHOTOFRIN (porfimer sodium) is a photosensitizing agent administered intravenously for photodynamic therapy (PDT), a light-activated cancer treatment. It works through a two-stage mechanism: IV injection followed by selective illumination with 630 nm laser light to generate reactive oxygen species and induce tumor cell death. The drug is retained longer in tumor tissue than normal tissue, enabling selective tumor targeting.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30), indicating contracting team size and shift toward lifecycle management rather than growth initiatives.
Mechanism of Action
12.1 Mechanism of Action The cytotoxic and antitumor actions of PHOTOFRIN are light and oxygen dependent. Photodynamic therapy (PDT) with PHOTOFRIN is a two-stage process. The first stage is the intravenous administration of PHOTOFRIN. Clearance from a variety of tissues occurs over 40-72 hours,…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.