NDARECTALSUPPOSITORY
Approved
Apr 1960
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
PHENERGAN (promethazine hydrochloride) by Teva is clinical pharmacology promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. First approved in 1960.
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PHENERGAN (promethazine HCl) is a first-generation phenothiazine derivative approved in 1960 that functions as an H1 receptor antagonist with clinically useful sedative and antiemetic properties. It is used for allergic conditions, nausea/vomiting, and sedation across multiple routes of administration. The drug's branched side-chain structure limits dopamine antagonism compared to antipsychotic phenothiazines, making it suitable for symptomatic relief rather than psychiatric indications.
LOE Approaching
As an LOE-approaching legacy product with moderate competitive pressure (30/100), roles focus on brand defense and managed decline rather than expansion; expect smaller, leaner teams.
Mechanism of Action
CLINICAL PHARMACOLOGY Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. It is thought that this configuration is responsible for its relative lack (1/10 that of…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Roles on PHENERGAN focus on brand defense, market maintenance, and regulatory compliance rather than expansion or launch activities. Working on a LOE-approaching legacy product offers stability and deep product knowledge but limited upward mobility within that brand.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.