NDAORALTABLET
Approved
Mar 1951
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
PHENERGAN (promethazine hydrochloride) by Teva is clinical pharmacology promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. First approved in 1951.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PHENERGAN (promethazine hydrochloride) is a first-generation phenothiazine derivative approved in 1951 that acts as an H1 receptor antagonist with additional sedative and antiemetic properties. It is well-absorbed orally with clinical effects within 20 minutes, lasting 4-6 hours (up to 12 hours). The drug is metabolized hepatically to sulfoxide and N-demethyl metabolites.
LOE Approaching
As an aging off-patent product with LOE approaching, brand support is likely minimal with skeleton team focused on retention rather than growth.
Mechanism of Action
CLINICAL PHARMACOLOGY Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. It is thought that this configuration is responsible for its relative lack (1/10 that of…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on PHENERGAN represents a career opportunity in defensive portfolio management and brand stewardship in a generic-saturated market. Positions emphasize compliance, market protection, and operational efficiency rather than growth or innovation.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.