NDAORALSYRUP
Approved
Mar 1962
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
PERIACTIN (cyproheptadine hydrochloride) by Merck & Co. is clinical pharmacology cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. First approved in 1962.
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PERIACTIN (cyproheptadine HCl) is an oral first-generation antihistamine and serotonin antagonist approved in 1962 with anticholinergic and sedative properties. It is used to treat allergic reactions, pruritus, urticaria, and appetite stimulation in pediatric and adult patients. The drug works by competitively blocking serotonin and histamine receptor sites.
LOE Approaching
As a legacy product approaching loss of exclusivity with 30% competitive pressure, the brand team is likely contracting or transitioning to generic support and niche pediatric positioning.
Mechanism of Action
CLINICAL PHARMACOLOGY Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites. Pharmacokinetics and Metabolism After a single 4 mg oral…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on PERIACTIN as a pharma professional means supporting a legacy product in mature/declining phase, with limited career growth in brand innovation or clinical development. Roles focus on operational efficiency, generic competition management, and defending pediatric/niche market segments rather than blockbuster growth.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.