PERCORTEN
LOE ApproachingNDAIMPLANTATIONPELLET
Approved
Dec 1942
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
PERCORTEN by Novartis is clinical pharmacology: desoxycorticosterone pivalate (docp), like other adrenocorticoid hormones, is thought to act by controlling the rate of synthesis of proteins. First approved in 1942.
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PERCORTEN (desoxycorticosterone pivalate/DOCP) is a long-acting mineralocorticoid ester administered as an intramuscular pellet implant for treatment of hypoadrenocorticism in animals. It works by controlling protein synthesis through steroid-receptor complexes that bind to chromatin, primarily increasing renal tubular sodium reabsorption and extracellular fluid volume to prevent hypotensive shock and pre-renal azotemia. This mechanism mirrors the natural hormone aldosterone and restores critical electrolyte and fluid balance in adrenal-insufficient patients.
LOE Approaching
Product approaching end-of-life with minimal competitive pressure (30%), suggesting consolidation of team resources and focus on retention rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY: Desoxycorticosterone pivalate (DOCP), like other adrenocorticoid hormones, is thought to act by controlling the rate of synthesis of proteins. It reacts with receptor proteins in the cytoplasm to form a steroid-receptor complex. This complex moves into the nucleus, where it…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.