NDAINJECTIONINJECTABLEPriority Review
Approved
Jul 1974
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
Priority Review
PEPTAVLON (pentagastrin) by Thayer Medical is clinical pharmacology the exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. First approved in 1974.
Drug data last refreshed 20h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PEPTAVLON (pentagastrin) is a synthetic gastrin analogue administered by injection that stimulates gastric acid, pepsin, and intrinsic factor secretion by exciting oxyntic cells to maximum capacity. It is used diagnostically to assess gastric acid secretory capacity and pancreatic function. The drug works through a mechanism believed to mimic natural gastrin, with onset in 10 minutes and peak effect at 20–30 minutes.
LOE Approaching
As a diagnostic agent with LOE approaching, the commercial team is likely small and focused on maintaining existing hospital/lab relationships rather than growth-stage expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY The exact mechanism by which Pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since Pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)
Started Sep 2002
60 enrolled
GERD
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.