PENTETATE CALCIUM TRISODIUM
LOE Approachingpentetate calcium trisodium
NDAINHALATION, INTRAVENOUSSOLUTIONPriority Review
Approved
Aug 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
Priority Review
PENTETATE CALCIUM TRISODIUM (pentetate calcium trisodium) is ca-dtpa forms stable chelates with metal ions by exchanging calcium for a metal of greater binding capacity. Approved for individuals with known, suspected internal contamination with plutonium, americium and 1 more indications. First approved in 2004.
Drug data last refreshed 15h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Pentetate calcium trisodium (Ca-DTPA) is an intravenous and inhalation chelation agent that forms stable complexes with radioactive metal ions (plutonium, americium, curium) and facilitates their urinary excretion. It is indicated for individuals with known or suspected internal contamination with transuranium elements to increase elimination rates. The drug works by exchanging calcium for metals with greater binding capacity, creating stable chelates that are renally cleared.
LOE Approaching
Niche product nearing loss of exclusivity with limited market size; small, specialized team focused on regulatory compliance and emergency response preparedness.
Mechanism of Action
Ca-DTPA forms stable chelates with metal ions by exchanging calcium for a metal of greater binding capacity. The radioactive chelates are then excreted by glomerular filtration into the urine. In animal studies, Ca-DTPA forms less stable chelates with uranium and neptunium in vivo resulting in the…
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.