NDAINTRAVENOUSSOLUTION
Approved
Jul 2022
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
15
Data completeness
3/8 — Basic
PEMETREXED DISODIUM (pemetrexed disodium) by Accord Biopharma is folate-dependent metabolic processes essential for cell replication. First approved in 2022.
Drug data last refreshed 37m ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Pemetrexed disodium is a folate antagonist small-molecule chemotherapy agent that inhibits multiple folate-dependent enzymes (thymidylate synthase, dihydrofolate reductase, and GARFT) essential for cell replication. It is administered intravenously and is primarily used in oncology for solid tumors where it disrupts nucleotide synthesis in rapidly dividing cells. The drug is converted intracellularly to active polyglutamate forms that are retained within cancer cells, enhancing its therapeutic effect.
Peak
Product is in peak commercial stage with moderate competitive pressure (30%), indicating stable market position and ongoing demand for specialized oncology sales and marketing teams.
Mechanism of Action
folate-dependent metabolic processes essential for cell replication. In vitro studies show that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase (GARFT), which are folate-dependent enzymes involved in the de novo biosynthesis…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (15)
Pemetrexed Disodium and Hsp90 Inhibitor AUY922 in Treating Patients With Previously Treated Stage IV Non-Small Cell Lung Cancer
Started Jan 2014
13 enrolled
Recurrent Non-small Cell Lung CancerSquamous Cell Lung CancerStage IV Non-small Cell Lung Cancer
Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy
Started Apr 2010
72 enrolled
Malignant Mesothelioma
Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer
Started Feb 2010
313 enrolled
Lung Cancer
Pemetrexed Disodium With or Without Sorafenib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Started Sep 2007
110 enrolled
Lung Cancer
Gemcitabine and Pemetrexed Disodium in Treating Patients With Advanced Mycosis Fungoides or Sézary Syndrome
Started Aug 2006
14 enrolled
Lymphoma
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.