PEMETREXED (pemetrexed sodium) by Teva is folate-dependent metabolic processes essential for cell replication. Approved for combination with cisplatin for the initial treatment of patients with malignant pleural mesothelioma whose disease is unresectable.
Drug data last refreshed 2w ago
folate-dependent metabolic processes essential for cell replication. In vitro studies show that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), which are folate-dependent enzymes involved in the de novo…
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